Phenylethylamine and Glucose in True Depression

The presence of phenylethylamine (PEA) in human urine was demonstrated by several investigators (Jepson et al., 1960; Perry, 1962; Oates et al., 1963; Fischer et al., 1968; Boulton and Mil-ward, 1971; Fischer et al., 1972; Mosnaim and Inwang, 1973; Schweitzer et al., 1975). Further, a decrease of PEA was reported in the urine of depressed patients (Fischer et al., 1972; Rodriguez Casanova and Fernandez Labriola, 1972; Boulton and Milward, 1971; Mosnaim et al., 1973), and an increase in schizophrenic patients (Fischer et al., 1972) and in a subgroup of migrainous patients (Sandler, 1972). It has been claimed that the administration of D or DL-phenyla-lanine for true depression has resulted in an improvement of their symptomatology (Yaryura-Tobias et al., 1974; Fischer et al., 1975; Nachon and Di Santo, 1974; Ipar et al., 1974; Spatz et